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Article

RNA-Binding Proteins: Splicing Factors and Disease.

Biomolecules - 13 May 2015

Fredericks Alger M, Cygan Kamil J, Brown Brian A, Fairbrother William G

Abstract excerpt

Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes. Disruptions in splicing are a major contributor to human disease. One in three hereditary disease alleles are believed to cause aberrant splicing. Hereditary disease alleles can alter splicing by disrupting a...

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Identifiers

PMID: 25985083
DOI: 10.3390/biom5020893
PMCID: PMC4496701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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