Improved accuracy of discrimination between IgM Multiple Myeloma and Waldenström Macroglobulinaemia by testing for <i><scp>MYD</scp>88</i> L265P mutations

Abstract excerpt

Immunoglobulin M (IgM) myelomas account for <0.5% of all myelomas (De Gramont et al, 1990) and are responsible for only a very small proportion of all IgM paraproteinaemias, estimated not to exceed 0.2% (Owen et al, 2000). In the largest published series, which included 10 patients, IgM myelomas were frequently associated with an immunophenotype negative for CD20, CD56 and CD117, the occurrence of a translocation...

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