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Article

IgM-MM is predominantly a pre-germinal center disorder and has a distinct genomic and transcriptomic signature from WM.

Blood - 18 Nov 2021

Bazarbachi Abdul Hamid, Avet-Loiseau Hervé, Szalat Raphael, Samur Anil Aktas, Hunter Zachary, Shammas Masood, Corre Jill, Fulciniti Mariateresa, Anderson Kenneth C, Parmigiani Giovanni, Treon Steven P, Mohty Mohamad, Munshi Nikhil C, Samur Mehmet Kemal

Abstract excerpt

Immunoglobulin M (IgM) multiple myeloma (MM) is a rare disease subgroup. Its differentiation from other IgM-producing gammopathies such as Waldenström macroglobulinemia (WM) has not been well characterized but is essential for proper risk assessment and treatment. In this study, we investigated genomic and transcriptomic characteristics of IgM-MM samples using whole-genome and transcriptome sequencing to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34792571
DOI: 10.1182/blood.2021011452
PMCID: PMC8602933

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