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Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS).

Cancer medicine - 1 Dec 2024

Trojani Alessandra, Beghini Alessandro, Bossi Luca Emanuele, Stefanucci Marta Rachele, Palumbo Cassandra, Greco Antonino, Frustaci Annamaria, Di Camillo Barbara, Cairoli Roberto

Abstract excerpt

BACKGROUND: Despite recurrent and activating mutations, including MYD88, CXCR4, ARID1A, KMT2D, and CD79B were identified, the genetic basis for Waldenström's Macroglobulinemia (WM) and the risk of progression of IgM MGUS to WM remain to be fully elucidated. METHODS: We investigated the mutation status of WM (n = 8), sWM (n = 7), and IgM MGUS (n = 5) patients, by performing high-throughput targeted AmpliSeq NGS on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39711167
DOI: 10.1002/cam4.70525
PMCID: PMC11664121

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