Article
Association of variants in genes involved in pancreatic β-cell development and function with type 2 diabetes in North Indians.
Journal of human genetics - 1 Oct 2011
Chavali Sreenivas, Mahajan Anubha, Tabassum Rubina, Dwivedi Om Prakash, Chauhan Ganesh, Ghosh Saurabh, Tandon Nikhil, Bharadwaj Dwaipayan
Abstract excerpt
Variants in genes involved in pancreatic β-cell development and function are known to cause monogenic forms of type 2 diabetes and are also associated with complex form. In this study, we studied the genetic association of polymorphisms in such important genes with type 2 diabetes in the high-risk Indians. We genotyped 91 polymorphisms in 19 genes (ABCC8, HNF1A, HNF1B, HNF4A, INS, INSM1, ISL1, KCNJ11, MAFA, MNX1,...
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