Article
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
PloS one - 1 Jan 2012
Florez Jose C, Jablonski Kathleen A, McAteer Jarred B, Franks Paul W, Mason Clinton C, Mather Kieren, Horton Edward, Goldberg Ronald, Dabelea Dana, Kahn Steven E, Arakaki Richard F, Shuldiner Alan R, Knowler William C
Abstract excerpt
Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped...
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