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Article

The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.

British journal of pharmacology - 1 Jun 2010

Samer C F, Daali Y, Wagner M, Hopfgartner G, Eap C B, Rebsamen M C, Rossier M F, Hochstrasser D, Dayer P, Desmeules J A

Abstract excerpt

BACKGROUND AND PURPOSE: There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 and 3A], due to genetic polymorphisms and/or drug-drug interactions. The effects of CYP2D6 and/or CYP3A activity modulation on the pharmacokinetics of oxycodone remains poorly explored. EXPERIMENTAL APPROACH: A randomized crossover...

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Identifiers

PMID: 20590587
DOI: 10.1111/j.1476-5381.2010.00673.x
PMCID: PMC2935997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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