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Article

Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

PloS one - 1 Jan 2013

Nakagawa Shin-ichiro, Hirata Yuichi, Kameyama Takeshi, Tokunaga Yuko, Nishito Yasumasa, Hirabayashi Kazuko, Yano Junichi, Ochiya Takahiro, Tateno Chise, Tanaka Yasuhito, Mizokami Masashi, Tsukiyama-Kohara Kyoko, Inoue Kazuaki, Yoshiba Makoto, Takaoka Akinori, Kohara Michinori

Abstract excerpt

BACKGROUND & AIMS: The interferon (IFN) system plays a critical role in innate antiviral response. We presume that targeted induction of IFN in human liver shows robust antiviral effects on hepatitis C virus (HCV) and hepatitis B virus (HBV). METHODS: This study used chimeric mice harboring humanized livers and infected with HCV or HBV. This mouse model permitted simultaneous analysis of immune responses by human...

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Identifiers

PMID: 23555725
DOI: 10.1371/journal.pone.0059611
PMCID: PMC3610702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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