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Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

23 Feb 2010

Abstract excerpt

A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has been an impediment to both furthering understanding of virus biology and testing antiviral therapies. We recently described a regulatable system for repopulating the liver of immunodeficient mice (specifically mice lacking fumaryl acetoacetate hydrolase [Fah], recombination activating gene 2 [Rag2], and...

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PMID: 20179355
DOI: 10.1172/jci40094

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