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Article

Dna2 initiates resection at clean DNA double-strand breaks.

Nucleic acids research - 16 Nov 2017

Paudyal Sharad C, Li Shan, Yan Hong, Hunter Tony, You Zhongsheng

Abstract excerpt

Nucleolytic resection of DNA double-strand breaks (DSBs) is essential for both checkpoint activation and homology-mediated repair; however, the precise mechanism of resection, especially the initiation step, remains incompletely understood. Resection of blocked ends with protein or chemical adducts is believed to be initiated by the MRN complex in conjunction with CtIP through internal cleavage of the 5' strand...

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Identifiers

PMID: 28981724
DOI: 10.1093/nar/gkx830
PMCID: PMC5714177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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