Article
Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes.
Neoplasia (New York, N.Y.) - 1 Apr 2013
Morrison Ludivine Coudière, McClelland Robyn, Aiken Christopher, Bridges Melissa, Liang Lisa, Wang Xin, Di Curzio Domenico, Del Bigio Marc R, Taylor Michael D, Werbowetski-Ogilvie Tamra E
Abstract excerpt
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Major research efforts have focused on characterizing and targeting putative brain tumor stem or propagating cell populations from the tumor mass. However, less is known about the relationship between these cells and highly invasive MB cells that evade current therapies. Here, we dissected MB cellular heterogeneity and directly...
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