Article
PLCz functional haplotypes modulating promoter transcriptional activity are associated with semen quality traits in Chinese Holstein bulls.
PloS one - 1 Jan 2013
Pan Qing, Ju Zhihua, Huang Jinming, Zhang Yan, Qi Chao, Gao Qin, Zhou Lei, Li Qiuling, Wang Lingling, Zhong Jifeng, Liu Mei, Wang Changfa
Abstract excerpt
The sperm-specific phospholipase C zeta (PLCz) is a candidate sperm-borne oocyte-activating factor that triggers a characteristic series of physiological stimuli via cytoplasmic Ca(2+) oscillations during fertilization. The molecular mechanisms involved in the regulation of PLCz gene expression remain largely unknown. To explore the genetic variations in the 5'-flanking region of the PLCz gene and their common...
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