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Article

A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11.

Genetics - 1 May 2005

Lee Grace S, Cantor Rita M, Abnoosian Arin, Park Euisun, Yamamoto Mitsuko L, Hovland David N, Collins Michael D

Abstract excerpt

All-trans-retinoic acid (RA) induces various anatomical limb dysmorphologies in mice dependent on the time of exposure. During early limb development, RA induces forelimb ectrodactyly (digital absence) with varying susceptibilities for different inbred mouse strains; C57BL/6N are highly susceptible while SWV are resistant. To isolate the genetic basis of this defect, a full-genome scan was performed in 406...

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Identifiers

PMID: 15781699
DOI: 10.1534/genetics.104.038620
PMCID: PMC1449723

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Source receipt: pubmed, retrieved 7 Sept 2026.

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