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Article

Ay allele promotes azoxymethane-induced colorectal carcinogenesis by macrophage migration in hyperlipidemic/diabetic KK mice.

Cancer science - 1 Jul 2013

Ito Kumiko, Ishigamori Rikako, Mutoh Michihiro, Ohta Toshihiro, Imai Toshio, Takahashi Mami

Abstract excerpt

The incidence of colorectal cancer has been increasing and is associated with obesity and diabetes. We have found that type 2 diabetes model KK-Ay/TaJcl (KK-Ay) mice develop tumors within a short period after treatment with azoxymethane (AOM). However, factors that contribute to the promotion of carcinogenesis have not been clarified. Therefore, we looked at the genetic background of KK-Ay, including two genetic...

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Identifiers

PMID: 23551905
DOI: 10.1111/cas.12162
PMCID: PMC7657178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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