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Article

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.

Cancer science - 1 Apr 2008

Tsuchihara Katsuya, Ogura Tsutomu, Fujioka Rumi, Fujii Satoshi, Kuga Wataru, Saito Marie, Ochiya Takahiro, Ochiai Atsushi, Esumi Hiroyasu

Abstract excerpt

SNF-1/5'-AMP-activated kinase (AMPK)-related kinase (SNARK) is a member of the AMPK-related kinases. Snark(+/-) mice exhibited mature-onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumorigenesis in the large intestine, obese Snark(+/-) mice were treated with a chemical carcinogen, azoxymethane (AOM)....

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Identifiers

PMID: 18307533
DOI: 10.1111/j.1349-7006.2008.00734.x
PMCID: PMC11158890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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