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Article

Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.

British journal of cancer - 2 Apr 2013

De Faveri L E, Hurst C D, Platt F M, Taylor C F, Roulson J-A, Sanchez-Carbayo M, Knowles M A, Chapman E J

Abstract excerpt

BACKGROUND: Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic silencing is reported. METHODS: NDN expression was examined in normal tissues and tumour cell...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23549060
DOI: 10.1038/bjc.2013.104
PMCID: PMC3619261

Genes

NDN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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