Article
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.
Molecular cancer - 21 May 2015
Heubach Judith, Monsior Juliana, Deenen René, Niegisch Günter, Szarvas Tibor, Niedworok Christian, Schulz Wolfgang Arthur, Hoffmann Michèle Janine
Abstract excerpt
BACKGROUND: Urothelial carcinoma (UC) is the fifth most common cancer in the developed world. Delineation of differentiation subtypes in UC highlighted the importance of aberrant differentiation. Understanding underlying mechanisms may facilitate diagnosis and development of efficient therapy strategies. It is well accepted that epigenetic mechanisms are involved. Long noncoding RNAs (lncRNAs), a new class of...
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