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Epigenetic modulation elicits an NK cell-mediated immune response in urothelial carcinoma

23 Jun 2025

Abstract excerpt

Urothelial carcinoma (UC), the second most prevalent cancer of the urothelial system, has demonstrated a well-developed ability to evade natural killer (NK) cell-mediated killing via various pathways, highlighting the need for innovative therapeutic approaches. Our study examines the role of cyproheptadine (CPH) and entinostat (ENT) as epigenetic modifiers in enhancing NK cell-mediated cytotoxicity against UC....

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40551137
DOI: 10.1186/s10020-025-01264-9

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