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Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer

28 Feb 2007

Abstract excerpt

BACKGROUND: Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals. RESULTS: We show that CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. For both genes, methylation was correlated with loss of gene transcription in human cell lines. Furthermore, demethylation of the NID1 and...

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PMID: 17328794
DOI: 10.1186/1476-4598-6-17

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