Article
Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993
Koo G C, Rosen H, Sirotina A, Ma X D, Shultz L D
Abstract excerpt
The effect of in vivo treatment with anti-CD11b (MAC-1) antibody (Ab) was examined in an inflammatory disease model, the viable moth-eaten (mev) mutant mouse. The autosomal recessive mev gene occurred spontaneously as a point mutation of the hematopoietic cell protein tyrosine phosphatase in C57B...
Topics
- Animals
- Antibodies, Monoclonal
- Bone Marrow
- Bone Marrow Transplantation
- Chimera
- Disease Models, Animal
- Inflammation
- Killer Cells, Natural
- Macrophage-1 Antigen
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Phenotype
- Protein Tyrosine Phosphatases
- T-Lymphocytes