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Article

Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993

Koo G C, Rosen H, Sirotina A, Ma X D, Shultz L D

Abstract excerpt

The effect of in vivo treatment with anti-CD11b (MAC-1) antibody (Ab) was examined in an inflammatory disease model, the viable moth-eaten (mev) mutant mouse. The autosomal recessive mev gene occurred spontaneously as a point mutation of the hematopoietic cell protein tyrosine phosphatase in C57BL/6 mice. Homozygotes (mev/mev) develop a chronic myelomonocytic inflammation, involving accumulation of myelomonocytic...

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Source

Identifiers

PMID: 8258688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.PMID 8258688Read ↗

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Common and individual features of the humoral immunity dysregulation of mice homozygous at the viable motheaten (mev) mutation.Semantic proximity Read ↗

DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.Semantic proximity Read ↗

Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.Semantic proximity Read ↗

B and T cells are not required for the viable motheaten phenotype.Semantic proximity Read ↗

Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.Semantic proximity Read ↗

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.Semantic proximity Read ↗

Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand/Fas system.Semantic proximity Read ↗

Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density.Semantic proximity Read ↗

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