Article
Genotype analysis of the NRF2 gene mutation in lung cancer.
International journal of molecular medicine - 1 May 2013
Sasaki Hidefumi, Suzuki Ayumi, Shitara Masayuki, Hikosaka Yu, Okuda Katsuhiro, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
Nuclear factor (erythroid derived 2)-like 2 (NRF2, gene name NFE2L2) gene mutations have been previously identified in lung cancers. The constitutive activation of NRF2 resulting from gene mutations has been correlated with the poor prognosis of patients with squamous cell lung cancer. However, DNA sequencing using PCR methods described to date is time-consuming and requires significant quantities of DNA. Thus,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.