Article
Mutation of the Nrf2 gene in non-small cell lung cancer.
Molecular biology reports - 1 Apr 2012
Hu Yi, Ju Yanfang, Lin Dongmei, Wang Zhikuan, Huang Yurong, Zhang Sujie, Wu Chao, Jiao Shunchang
Abstract excerpt
Nrf2 (NFE2L2) is a transcription factor belonging to the Cap'N'Collar subfamily of basic-leucine zipper (bZIP) family of transcription factors, which plays a significant role in adaptive responses to oxidative stress. To investigate the relationship of between the mutation of Nrf2 gene and non-small cell lung cancer (NSCLC), in this study, we sequenced the Nrf2 gene from a total of 103 patients with NSCLC and...
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