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Article

Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas.

Molecular medicine reports - 1 Aug 2012

Sasaki Hidefumi, Shitara Masayuki, Yokota Keisuke, Hikosaka Yu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor belonging to the cap 'n' collar subfamily of the basic-leucine zipper (bZIP) family of transcription factors, which plays a significant role in adaptive responses to oxidative stress. Previously, we reported that NRF2 gene (NFE2L2) mutations correlate with poor prognosis of lung squamous cell carcinomas. We therefore hypothesized that an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22614957
DOI: 10.3892/mmr.2012.921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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