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Article

Impact of novel polymorphisms related to cytotoxicity of cytarabine in the induction treatment of acute myeloid leukemia.

Pharmacogenetics and genomics - 1 Jul 2017

Megías-Vericat Juan E, Montesinos Pau, Herrero María J, Moscardó Federico, Bosó Virginia, Martínez-Cuadrón David, Poveda José L, Sanz Miguel Á, Aliño Salvador F

Abstract excerpt

Several novel single nucleotide polymorphisms (SNPs) involved in cytarabine cytotoxicity and related to clinical outcomes have been reported recently in a series of 232 pediatric patients with acute myeloid leukemia (AML). We report the first adult AML cohort in which the influence of these SNPs in cytarabine efficacy and toxicity was analyzed. Six of polymorphisms with clinical significance in the previous study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28570300
DOI: 10.1097/FPC.0000000000000286

Genes

MCC
IRX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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