Article
Genome-wide associations of signaling pathways in glioblastoma multiforme.
BMC medical genomics - 28 Mar 2013
Wuchty Stefan, Vazquez Alexei, Bozdag Serdar, Bauer Peter O
Abstract excerpt
BACKGROUND: eQTL analysis is a powerful method that allows the identification of causal genomic alterations, providing an explanation of expression changes of single genes. However, genes mediate their biological roles in groups rather than in isolation, prompting us to extend the concept of eQTLs to whole gene pathways. METHODS: We combined matched genomic alteration and gene expression data of glioblastoma...
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