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Article

Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways.

International journal of molecular sciences - 30 Jun 2022

Zolotovskaia Marianna A, Kovalenko Max A, Tkachev Victor S, Simonov Alexander M, Sorokin Maxim I, Kim Ella, Kuzmin Denis V, Karademir-Yilmaz Betul, Buzdin Anton A

Abstract excerpt

In gliomas, expression of certain marker genes is strongly associated with survival and tumor type and often exceeds histological assessments. Using a human interactome model, we algorithmically reconstructed 7494 new-type molecular pathways that are centered each on an individual protein. Each single-gene expression and gene-centric pathway activation was tested as a survival and tumor grade biomarker in gliomas...

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Identifiers

PMID: 35806337
DOI: 10.3390/ijms23137330
PMCID: PMC9266372

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