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Article

Retinoic acid deficiency impairs the vestibular function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Mar 2013

Romand Raymond, Krezel Wojciech, Beraneck Mathieu, Cammas Laura, Fraulob Valérie, Messaddeq Nadia, Kessler Pascal, Hashino Eri, Dollé Pascal

Abstract excerpt

The retinaldehyde dehydrogenase 3 (Raldh3) gene encodes a major retinoic acid synthesizing enzyme and is highly expressed in the inner ear during embryogenesis. We found that mice deficient in Raldh3 bear severe impairment in vestibular functions. These mutant mice exhibited spontaneous circling/tilted behaviors and performed poorly in several vestibular-motor function tests. In addition, video-oculography...

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Identifiers

PMID: 23536097
DOI: 10.1523/JNEUROSCI.4618-12.2013
PMCID: PMC6705067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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