Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

doi:10.1038/ng0496-390

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Article

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

Nature genetics - 1 Apr 1996

Colvin J S, Bohne B A, Harding G W, McEwen D G, Ornitz D M

Abstract excerpt

Fibroblast growth factor receptor 3 (Fgfr3) is a tyrosine kinase receptor expressed in developing bone, cochlea, brain and spinal cord. Achondroplasia, the most common genetic form of dwarfism, is caused by mutations in FGFR3. Here we show that mice homozygous for a targeted disruption of Fgfr3 e...

Topics

Achondroplasia
Animals
Bone Diseases, Developmental
DNA
Deafness
Ear, Inner
Female
Gene Targeting
Homozygote
Humans
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Osteogenesis
Phenotype
Protein-Tyrosine Kinases

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