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Article

Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density.

Behavioral neuroscience - 1 Apr 2012

Cao Yufei A, Featherstone Robert E, Gandal Michael J, Liang Yuling, Jutzeler Catherine, Saunders John, Tatard-Leitman Valerie, Chen Jingshan, Weinberger Daniel R, Lerman Caryn, Siegel Steven J

Abstract excerpt

Regulation of dopamine neurotransmission is essential for cognitive processes. In humans and rodents, the relationship between dopamine signaling and cognitive performance is described as a dose-dependent, inverted-U curve whereby excess or insufficiency of dopamine in prefrontal cortex has detrimental effects. Previous studies have indicated that prefrontal dopamine levels are associated with genetic variation...

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Source

Identifiers

PMID: 22309446
DOI: 10.1037/a0027047

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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