Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sclerostin: a novel target for intervention in the treatment of osteoporosis.

Discovery medicine - 1 Oct 2011

Lewiecki E Michael

Abstract excerpt

Bone remodeling is the process by which the adult skeleton is continually renewed through the highly coordinated activity of three types of cells - osteoclasts, osteoblasts, and osteocytes. Disruptions in signaling among these cells and alterations in their activity have been associated with skeletal diseases. In a rare accident of nature, some families have been found to have dense and strong bones due to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Antibodies, Monoclonal
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SOST gene

Share to Genetic Markers

Share to Mutation

Share to Osteoporosis

Source

Identifiers

PMID: 22031665

Genes

SOST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sclerostin: a novel target for intervention in the treatment of osteoporosis.PMID 22031665Read ↗

Sclerostin: Current Knowledge and Future PerspectivesSemantic proximity Read ↗

The Role of Sclerostin in Bone DiseasesSemantic proximity Read ↗

SclerostinSemantic proximity Read ↗

SclerostinSemantic proximity Read ↗

Update on romosozumab: a humanized monoclonal antibody to sclerostinSemantic proximity Read ↗

The sclerostin story: From human genetics to the development of novel anabolic treatment for osteoporosisSemantic proximity Read ↗

Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal modelsSemantic proximity Read ↗

Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt SignalingSemantic proximity Read ↗

Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis.Semantic proximity Read ↗

SOST/sclerostin, an osteocyte-derived negative regulator of bone formationSemantic proximity Read ↗

Endocrine functions of sclerostinSemantic proximity Read ↗

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.