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Endocrine functions of sclerostin

20 Dec 2022

Abstract excerpt

Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation. In this review, we discuss emerging data which suggest that sclerostin also acts outside the skeleton to influence metabolism. In humans, serum sclerostin...

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Identifiers

PMID: 36713826
DOI: 10.1016/j.coemr.2022.100433

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