Article
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Rauthan Manish, Ranji Parmida, Aguilera Pradenas Nataly, Pitot Christophe, Pilon Marc
Abstract excerpt
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via the mevalonate pathway. This pathway also produces coenzyme Q (a component of the respiratory chain), dolichols (important for protein glycosylation), and isoprenoids (lipid moieties responsible for the membrane association of small GTPases). We...
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