Article
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Sapir Amir, Tsur Assaf, Koorman Thijs, Ching Kaitlin, Mishra Prashant, Bardenheier Annabelle, Podolsky Lisa, Bening-Abu-Shach Ulrike, Boxem Mike, Chou Tsui-Fen, Broday Limor, Sternberg Paul W
Abstract excerpt
Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of sterol and nonsterol isoprenoids, such as cholesterol and ubiquinone, as well as other metabolites. In humans, an age-dependent decrease in ubiquinone levels and...
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