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Article

Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children.

Gene - 10 Jun 2013

Bellusci Carolina P, Rocco Carlos, Aulicino Paula, Mecikovsky Debora, Curras Verónica, Hegoburu Soledad, Bramuglia Guillermo F, Bologna Rosa, Sen Luisa, Mangano Andrea

Abstract excerpt

BACKGROUND: Variability in MDR1 and PXR has been associated with differences in drug plasma levels and response to antiretroviral therapy. We investigated whether polymorphisms in MDR1 (T-129C, C1236T and C3435T) and PXR (C63396T) affect lopinavir plasma concentration and the virological or immunological response to HAART in HIV-1-infected children. METHODS: Genotypes were identified in 100 blood donors and 38...

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Identifiers

PMID: 23528223
DOI: 10.1016/j.gene.2013.03.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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