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Telomerase in Cancer: Function, Regulation, and Clinical Translation

5 Feb 2022

Abstract excerpt

During the process of malignant transformation, cells undergo a series of genetic, epigenetic, and phenotypic alterations, including the acquisition and propagation of genomic aberrations that impart survival and proliferative advantages. These changes are mediated in part by the induction of replicative immortality that is accompanied by active telomere elongation. Indeed, telomeres undergo dynamic changes to...

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PMID: 35159075
DOI: 10.3390/cancers14030808

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