Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Telomerase in Cell Senescence and Oncogenesis

1 Feb 2000

Abstract excerpt

The ends of linear chromosomes are capped by specialized nucleoprotein structures termed telomeres. Telomeres comprise tracts of noncoding hexanucleotide repeat sequences that, in combination with specific proteins, protect against degradation, rearrangement, and chromosomal fusion events. Due to the polarity of conventional DNA synthesis, a net loss of telomeric sequences occurs at each cell division. It has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10774453
DOI: 10.1146/annurev.med.51.1.65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Telomerase in Cell Senescence and OncogenesisPMID 10774453Read ↗

Telomeres and telomerase in cancerSemantic proximity Read ↗

Telomeres and telomerase in oncogenesis (Review)Semantic proximity Read ↗

Telomeres and telomerase: biological and clinical importanceSemantic proximity Read ↗

Role of telomerase in cellular proliferation and cancerSemantic proximity Read ↗

Hallmarks of telomeres in ageing researchSemantic proximity Read ↗

Role of Telomerase in Normal and Cancer CellsSemantic proximity Read ↗

Implications of telomere‐independent activities of telomerase reverse transcriptase in human cancerSemantic proximity Read ↗

Telomerase in Cancer: Function, Regulation, and Clinical TranslationSemantic proximity Read ↗

Role of Telomeres and Telomerase in Aging and CancerSemantic proximity Read ↗

Telomeres and Telomerase: Implications for Cancer and AgingSemantic proximity Read ↗

Current Insights to Regulation and Role of Telomerase in Human DiseasesSemantic proximity Read ↗

Telomerase activity in human cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.