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Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential

14 Jul 2020

Abstract excerpt

Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells, eventually resulting in replicative senescence once telomere length becomes critically short. Telomere shortening can be overcome by telomerase enzyme activity that is undetectable in...

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PMID: 32674474
DOI: 10.3390/cancers12071901

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