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Human Telomerase and Its Regulation

1 Sept 2002

Abstract excerpt

The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins. It is essential for maintaining the integrity and stability of linear eukaryotic genomes. Telomere length regulation and maintenance contribute to normal human cellular aging and human diseases. The synthesis of telomeres is mainly achieved by the cellular...

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Identifiers

PMID: 12208997
DOI: 10.1128/mmbr.66.3.407-425.2002

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