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Article

Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility.

The Journal of biological chemistry - 10 Aug 2018

Leighton Patricia L A, Kanyo Richard, Neil Gavin J, Pollock Niall M, Allison W Ted

Abstract excerpt

Normally folded prion protein (PrPC) and its functions in healthy brains remain underappreciated compared with the intense study of its misfolded forms ("prions," PrPSc) during the pathobiology of prion diseases. This impedes the development of therapeutic strategies in Alzheimer's and prion diseases. Disrupting the zebrafish homologs of PrPC has provided novel insights; however, mutagenesis of the zebrafish...

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Share to Animals, Genetically Modified
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29903907
DOI: 10.1074/jbc.RA117.001171
PMCID: PMC6093244

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