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Article

An ancient conserved role for prion protein in learning and memory

1 Jan 2018

Abstract excerpt

The misfolding of cellular prion protein (PrPC) to form PrP Scrapie (PrPSc) is an exemplar of toxic gain-of-function mechanisms inducing propagated protein misfolding and progressive devastating neurodegeneration. Despite this, PrPC function in the brain is also reduced and subverted during prion disease progression; thus understanding the normal function of PrPC in healthy brains is key. Disrupting PrPC in mice...

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PMID: 29358166
DOI: 10.1242/bio.025734

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