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Article

ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram.

International journal of legal medicine - 1 May 2013

Karlsson L, Green H, Zackrisson A L, Bengtsson F, Jakobsen Falk I, Carlsson B, Ahlner J, Kugelberg F C

Abstract excerpt

P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood-brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In this study, we aimed to investigate the frequency of ABCB1 genotypes in forensic autopsy cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23515680
DOI: 10.1007/s00414-013-0849-0

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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