Article
ABCB1 gene polymorphisms are associated with suicide in forensic autopsies.
Pharmacogenetics and genomics - 1 Sept 2013
Boiso Moreno Samuel, Zackrisson Anna-Lena, Jakobsen Falk Ingrid, Karlsson Louise, Carlsson Björn, Tillmar Andreas, Kugelberg Fredrik C, Ahlner Johan, Hägg Staffan, Gréen Henrik
Abstract excerpt
BACKGROUND: Polymorphisms in ABCB1 have the ability to affect both the function and the expression of the transporter protein P-glycoprotein and may lead to an altered response for many drugs including some antidepressants and antipsychotics. OBJECTIVE: The aim of this study was to examine the impact of the ABCB1 polymorphisms 1199G>A, 1236C>T, 2677G>T/A, and 3435C>T in deaths by suicide. PATIENTS AND METHODS: A...
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