Article
Effect of the copper-responsive factor Cuf1 on the capsule biosynthesis in Cryptococcus neoformans.
Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Nov 2009
Jiang Nan, Liu Xiaoguang, Pan Jiao, Wang Yajie, Zhu Xudong
Abstract excerpt
OBJECTIVE: Cryptococcus neoformans is an opportunistic human fungal pathogen that primarily infects immunocompromised patients. The most distinctive feature of C. neoformans is that it contains a highly regulated major virulence factor, the polysaccharide capsule. We demonstrate in this paper that a copper-dependent transcription factor gene CUF1 has a negative role in capsule biosynthesis. METHODS: Colony...
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