Article
Zebrafish model for human long QT syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2007
Arnaout Rima, Ferrer Tania, Huisken Jan, Spitzer Kenneth, Stainier Didier Y R, Tristani-Firouzi Martin, Chi Neil C
Abstract excerpt
Long QT syndrome (LQTS) is a disorder of ventricular repolarization that predisposes affected individuals to lethal cardiac arrhythmias. To date, an appropriate animal model of inherited LQTS does not exist. The zebrafish is a powerful vertebrate model used to dissect molecular pathways of cardiovascular development and disease. Because fundamental electrical properties of the zebrafish heart are remarkably...
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