Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.

doi:10.1186/s12985-018-0984-9

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Article

Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.

Virology journal - 2 May 2018

Socorro de Almeida Viana Maria de Nazaré do, Santos Nobre Akim Felipe, Costa Edivaldo, Silva Ingrid Christiane, Pinheiro Bruna Teles, Pereira Cássia Cristine Costa, de Souza Canto Ferreira Louise, de Almeida Danilo Souza, de Araújo Marcos William Leão, da Silva Borges Mariza, da Costa Carlos Araujo, Ishikawa Edna Aoba Yassui, Ferrari Stephen Francis, Silva de Sousa Maísa

Abstract excerpt

BACKGROUND: The human T-lymphotropic virus type 1 (HTLV-1) affects 2-5 million people worldwide, and is associated with a number of degenerative and infectious diseases. The Envelope glycoproteins (gp) are highly conserved among the different HTLV-1 isolates, although nucleotide substitutions in the region that codifies these proteins may influence both the infectivity and the replication of the virus. The gp46...

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PMID: 29716616
DOI: 10.1186/s12985-018-0984-9
PMCID: PMC5930498

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