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Article

Whole-genome haplotyping by dilution, amplification, and sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2013

Kaper Fiona, Swamy Sajani, Klotzle Brandy, Munchel Sarah, Cottrell Joseph, Bibikova Marina, Chuang Han-Yu, Kruglyak Semyon, Ronaghi Mostafa, Eberle Michael A, Fan Jian-Bing

Abstract excerpt

Standard whole-genome genotyping technologies are unable to determine haplotypes. Here we describe a method for rapid and cost-effective long-range haplotyping. Genomic DNA is diluted and distributed into multiple aliquots such that each aliquot receives a fraction of a haploid copy. The DNA template in each aliquot is amplified by multiple displacement amplification, converted into barcoded sequencing libraries...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23509297
DOI: 10.1073/pnas.1218696110
PMCID: PMC3619281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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