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Article

Clone-based systematic haplotyping (CSH): a procedure for physical haplotyping of whole genomes.

Genome research - 1 Dec 2003

Burgtorf Carola, Kepper Pamela, Hoehe Margret, Schmitt Carsten, Reinhardt Richard, Lehrach Hans, Sauer Sascha

Abstract excerpt

We present a novel methodology to determine the phase of single-nucleotide polymorphisms (SNPs) on a chromosome, which we term clone-based systematic haplotyping (CSH). The CSH procedure is based on separating the allelic chromosomes of a diploid genome by fosmid/cosmid cloning, and subsequent SNP typing of 96 clone pools, each representing approximately 10% of the genome. The pools are screened by PCR for the...

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Identifiers

PMID: 14656974
DOI: 10.1101/gr.1442303
PMCID: PMC403814

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