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Article

The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease.

BMC medical genetics - 18 Mar 2013

Vasseur Francis, Sendid Boualem, Broly Franck, Gower-Rousseau Corinne, Sarazin Aurore, Standaert-Vitse Annie, Colombel Jean-Frederic, Poulain Daniel, Jouault Thierry

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is associated with elevated anti-glycans antibody response in 60% of CD patients, and 25% of healthy first-degree relatives (HFDRs), suggesting a genetic influence for this humoral response. In mice, anti-glucan antibody response depends on the NLRP3 inflammasome. Here, we explored the effect of mutated CARD8, a component of the inflammasome, on anti-glycans antibody response in...

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Source

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Identifiers

PMID: 23506543
DOI: 10.1186/1471-2350-14-35
PMCID: PMC3608972

Genes

CARD8
NLRP3
NOD1
NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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