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Article

Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease.

Inflammatory bowel diseases - 1 Jan 2010

Joossens Marie, Van Steen Kristel, Branche Julien, Sendid Boualem, Rutgeerts Paul, Vasseur Francis, Poulain Daniel, Broly Franck, Colombel Jean-Frédéric, Vermeire Séverine, Chamaillard Mathias

Abstract excerpt

BACKGROUND: An increased risk of Crohn's disease (CD) has been reported consistently in first-degree relatives of patients. Our aim was to test whether a combination of CD-associated genes involved in innate immunity and/or antibody responses to microbial antigens may be valuable in identifying healthy relatives at risk. METHODS: We investigated 86 families from Belgium and northern France, 45 with at least 3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19504613
DOI: 10.1002/ibd.20985

Genes

NOD2
CARD8
NOD1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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