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Article

Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.

Gut - 1 Nov 2007

Henckaerts Liesbet, Pierik Marie, Joossens Marie, Ferrante Marc, Rutgeerts Paul, Vermeire Séverine

Abstract excerpt

BACKGROUND AND AIMS: A number of antibodies against microbial epitopes or self-antigens have been associated with Crohn's disease. The development of antibodies reflects a loss of tolerance to intestinal bacteria that underlies Crohn's disease, resulting in an exaggerated adaptive immune response to these bacteria. It was hypothesised that the development of antimicrobial antibodies is influenced by the presence...

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Topics

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Share to Antibody Formation
Share to Antigens, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Surface

Share to Cohort Studies

Share to Gene Frequency

Share to Inflammatory Bowel Diseases

Share to Polymorphism, Genetic

Share to Receptors, Pattern Recognition

Source

Open in PubMed Open full text

Identifiers

PMID: 17595233
DOI: 10.1136/gut.2007.125468
PMCID: PMC2095669

Genes

NOD1
TLR2
TLR4
CARD8
TLR1
TLR6
NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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