Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.

Gut - 1 Nov 2007

Henckaerts Liesbet, Pierik Marie, Joossens Marie, Ferrante Marc, Rutgeerts Paul, Vermeire Séverine

Abstract excerpt

BACKGROUND AND AIMS: A number of antibodies against microbial epitopes or self-antigens have been associated with Crohn's disease. The development of antibodies reflects a loss of tolerance to intestinal bacteria that underlies Crohn's disease, resulting in an exaggerated adaptive immune response...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Antigens, Bacterial
Share to Antigens, Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Gene Frequency

Share to Inflammatory Bowel Diseases

Share to Polymorphism, Genetic

Share to Receptors, Pattern Recognition

Source

Open in PubMed Open full text

Identifiers

PMID: 17595233
DOI: 10.1136/gut.2007.125468
PMCID: PMC2095669

Genes

NOD1
TLR2
TLR4
CARD8
TLR1
TLR6
NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17595233-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.PMID 17595233Read ↗

Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: is there a role for defensins?Semantic proximity Read ↗

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease.Semantic proximity Read ↗

New serological markers for inflammatory bowel disease are associated with earlier age at onset, complicated disease behavior, risk for surgery, and NOD2/CARD15 genotype in a Hungarian IBD cohort.Semantic proximity Read ↗

Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients.Semantic proximity Read ↗

The prevalence of genetic and serologic markers in an unselected European population-based cohort of IBD patients.Semantic proximity Read ↗

Crohn's disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis.Semantic proximity Read ↗

Genetics of the innate immune response in inflammatory bowel disease.Semantic proximity Read ↗

Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn' s disease population.Semantic proximity Read ↗

Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype.Semantic proximity Read ↗

Abnormalities in the handling of intracellular bacteria in Crohn's disease: a link between infectious etiology and host genetic susceptibility.Semantic proximity Read ↗

Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD study.Semantic proximity Read ↗

Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.